The trafficking of NaV1.8
نویسندگان
چکیده
The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.8 is selectively expressed in sensory neurons. It has been reported that Na(V)1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus Na(V)1.8 has been a promising target to treat chronic pain. Here we discuss the recent advances in the study of trafficking mechanism of Na(V)1.8. These pieces of information are particularly important as such trafficking machinery could be new targets for painkillers.
منابع مشابه
Modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C.
Voltage-gated Na+ channels (VGSC) are transmembrane proteins that are essential for the initiation and propagation of action potentials in neuronal excitability. Because neurons express a mixture of Na+ channel isoforms and protein kinase C (PKC) isozymes, the nature of which channel is being regulated by which PKC isozyme is not known. We showed that DRG VGSC Nav1.7 (TTX-sensitive) and Nav1.8 ...
متن کاملA Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line
Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological studies. However, NaV1.8 expresses no or low-level functional currents when transiently transfected into non-neuronal cell lines. The present study ...
متن کاملLidocaine promotes the trafficking and functional expression of Nav1.8 sodium channels in mammalian cells Abbreviated Title: Functional expression of Nav1.8 in tsA201 cells
Nociceptive neurons of the dorsal root ganglion (DRG) express a combination of rapidly gating TTX-sensitive and slowly gating TTX-resistant Na currents and the channels that produce these currents have been cloned. The Na v 1.7 and Na v 1.8 channels encode for the rapidly inactivating TTX-sensitive and slowly inactivating TTX-resistant Na currents respectively. Although the Na v 1.7 channel exp...
متن کاملInternational Human Trafficking: Critical Appraisal of Strength and Weaknesses of Nigeria’s Legal Frameworks
Nigeria has been facing the immense challenge of international trafficking in persons for sexual exploitation and forced labor into countries in Europe, Asia and Africa. Being an international criminal activity driven by high profits, Nigeria's adoption of a regulatory policy is expressed in the series of legal provisions to deal with the army of traffickers. In desperation, within a space of 1...
متن کاملTrafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.
Voltage-gated sodium channels (Navs) comprise at least nine pore-forming α subunits. Of these, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 are the most frequently studied in primary sensory neurons located in the dorsal root ganglion and are mainly localized to the cytoplasm. A large pool of intracellular Navs raises the possibility that changes in Nav trafficking could alter channel function. The molecu...
متن کامل